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Abstract
Background: Benign prostatic hyperplasia (BPH) is a common condition in aging men, and inflammation may contribute to its development and progression. Prostate-specific antigen (PSA) can be elevated in BPH, while C-reactive protein (CRP) may reflect systemic inflammatory activity. This study evaluated the relationship between PSA and CRP in patients with BPH.
Objective: To determine the correlation between serum PSA and CRP levels in patients with BPH.
Methods: This cross-sectional study was conducted at the Department of Medicine, Khyber Teaching Hospital, Peshawar, from 20 November 2024 to 25 March 2025. A total of 347 male patients aged 40–80 years with BPH diagnosed by ultrasonography were enrolled through consecutive sampling. Serum PSA and CRP levels were measured, and their correlation was assessed using Pearson's correlation coefficient. Stratified analyses were performed according to age, BMI, comorbidities, and prostate size.
Results: The mean age was 62.4 ± 8.7 years and mean prostate size was 48.6 ± 16.2 g. Mean PSA was 5.21 ± 3.84 ng/mL, while median CRP was 0.72 (IQR: 0.38–1.34) mg/dL. A significant positive correlation was observed between PSA and CRP (r = 0.28, p < 0.001).
Conclusion: PSA and CRP demonstrated a weak but significant positive correlation in patients with BPH, suggesting a possible association between systemic inflammation and PSA elevation.