KNOWLEDGE OF TUMOR LYSIS SYNDROME MANAGEMENT AMONG NURSES AT A TERTIARY CARE HOSPITAL IN KARACHI

Abstract

Tumor Lysis Syndrome (TLS) is a potentially life-threatening oncologic emergency characterized by severe metabolic disturbances resulting from the rapid destruction of malignant cells. Nurses play a pivotal role in the early identification, prevention, and management of TLS; therefore, adequate knowledge is essential for ensuring patient safety and improving clinical outcomes. This study aimed to assess the knowledge of Tumor Lysis Syndrome management among nurses working in a tertiary care hospital. A quantitative, descriptive cross-sectional research design was employed to achieve the study objective. The study was conducted among 33 registered nurses selected through a convenience sampling technique. Data were collected using a structured self-administered questionnaire consisting of demographic characteristics and knowledge-based questions related to the definition, risk factors, clinical manifestations, prevention, monitoring, and emergency management of TLS. The validity of the instrument was ensured through expert review, and ethical considerations were maintained throughout the study. Data were entered and analyzed using the Statistical Package for Social Sciences (SPSS) version 26. Descriptive statistics, including frequencies, percentages, means, and standard deviations, were used to summarize the findings.The results indicated that nurses possessed an overall satisfactory level of knowledge regarding Tumor Lysis Syndrome. Most participants correctly identified the definition of TLS, high-risk patients, the significance of hydration, laboratory monitoring, prevention of hyperuricemia, and the management of hyperkalemia-related complications. However, some knowledge gaps were observed in specific areas related to emergency nursing management and pharmacological interventions. The study concluded that while nurses demonstrated adequate knowledge of TLS management, continuous professional education is necessary to address identified deficiencies and maintain competency in managing oncologic emergencies. Based on the findings, it is recommended that healthcare institutions implement regular in-service training programs, simulation-based learning activities, and evidence-based clinical guidelines to strengthen nurses’ knowledge and enhance the quality and safety of patient care