Abstract
Skin rejuvenation and atrophic acne scar remodeling remain important challenges in contemporary dermatology due to their physical, aesthetic, and psychological impacts. Regenerative therapies such as platelet-rich plasma (PRP) and exosome therapy have gained increasing attention because of their potential to stimulate tissue repair, collagen regeneration, and dermal remodeling. However, direct comparative evidence between these treatment modalities remains limited. This study aimed to compare the clinical efficacy, safety, and patient-reported outcomes of PRP and exosome therapy in skin rejuvenation and acne scar remodeling.
A prospective, multicenter, comparative interventional study was conducted involving 40 participants aged 18 to 45 years with hyperpigmentation or atrophic acne scars. Participants received either PRP therapy (n = 24) or exosome therapy (n = 16). Clinical outcomes were assessed using photographic evaluation, scar severity scoring, patient satisfaction questionnaires, and safety monitoring. Data were analysed using SPSS version 26.0 through descriptive statistics, independent sample t-tests, effect size analysis, and chi-square tests.
The study concludes that PRP and exosome therapy are both effective and safe regenerative treatment options for skin rejuvenation and acne scar remodeling. Although exosome therapy represents a promising emerging approach, current evidence suggests comparable clinical performance between the two modalities. Further large-scale randomized studies with longer follow-up periods are recommended to establish long-term efficacy and standardized treatment protocols.