Abstract
Background:Due to reducing ovarian follicular function and lower estrogen synthesis, menopause is a usual physiological change in women characterized by the lasting end of menstruation, which reasons major hormonal and metabolic changes. These hormonal variations have the possible to impact lipid metabolism also thyroid function, which can increase the risk of metabolic diseases and heart disease.
Objective:The recent research aimed to study the relationship between menopausal position and serum thyroid-stimulating hormone (TSH) amounts as well as lipid profile measures in premenopausal and postmenopausal women.
Methods:Ethical permission was acquired before this cross-sectional research remained was conducted Novo Care International Hospital in Sargodha for a period of three months. Based on their menstrual history, 301 women were selected using non-random convenience sampling and separated into premenopausal and postmenopausal groups. Age, body mass index (BMI), height, weight, and medical history were among the population characteristics that were collected. Lipid profile indicator, such as total cholesterol, triglycerides, LDL, and VLDL, as well as serum TSH levels, were analyzed by obtaining blood samples. Regression examination using standardized coefficients, one-way ANOVA, and descriptive numerically were used to statistically analyze the relationship between biochemical factors and menopausal status.
Results:The connection between menopause and increasing age was clear, associate the notion that menopause is a biological change connected with age. Differences in thyroid function during reproductive aging were presented by a sturdy correlation between serum TSH levels and menopausal state. Menopausal metabolic changes are multifactorial, as proved by the restricted independent statistical role of differences in lipid profile parameters between groups within the regression model.
Conclusion: The outcomes expose that menopause is related to major hormonal and metabolic changes that capacity makes women more liable to thyroid disorders and cardiovascular disease. For the early identification of metabolic irregularities and the implementation of preventative healthcare involvements to enhance long-term health outcomes and excellence of life among aging women, routine monitoring of serum TSH and lipid profile during menopause is advised