Abstract
Background: Nephrotic syndrome is one of the most prevalent chronic kidney diseases among children and is marked by the symptoms of massive proteinuria, hypoalbuminemia, hyper lipidaemia and edema, which have significant metabolic repercussions for vitamin D, calcium, and renal health. Vitamin D deficiency can further exacerbate immunologic dysregulation, make infections more likely, and cause worse proteinuria, thus complicating the course of the disease. Although there is a need for evaluating vitamin D, calcium, and renal function parameters due to their significance for clinical outcomes in nephrotic syndrome, there is an insufficient focus on their assessment in children with nephrotic syndrome.
Objective: To evaluate the serum levels of vitamin D, calcium and Rfts in children suffering with nephrotic syndrome.
Methodology: It was Retrospective Observational study to evaluate serum vitamin D and calcium levels in children suffering with nephrotic syndrome. The study conducted at Children Hospital and collaborating paediatric nephrology units Total duration of study will be 4 months. Sample size = 91 (Sample size was calculated using the Cochran’s formula).
Results: A total of 91 children with nephrotic syndrome were included in this study. The average age of the participants was11.08 years of age with an SDof4.20, weight was11.08kg with SD of 4.20, and height was 84.10 cm with SD of 16.62, indicating that there was some variation in development among the participants. In terms of gender, the distribution is almost equal with 47 (51.6) being males and 44 (48.4) being females. Overall, the demographic data show a balanced population in terms of gender and heterogeneous distribution of age, weight, and height, providing a solid baseline for evaluating laboratory parameters in these children
Conclusion: The present study concludes that children with nephrotic syndrome exhibit significant abnormalities in vitamin D, calcium, and renal function parameters. Serum vitamin D is correlated weakly with serum calcium indicating that the status of vitamin D alone is not a predictor of calcium levels in this population.