Abstract
Antigens of the blood groups are involved in predisposition to various infectious illnesses, such as malaria, COVID-19, cholera, Norovirus etc. and non-infectious diseases such as cardiovascular diseases, venous thromboembolism, diabetes mellitus, and various forms of malignancies, including gastric cancer. The purpose of the review is to establish the association in various disease outcomes and polymorphism of blood groups. The antigen’s function in the development of numerous infectious and non-infectious diseases is achieved in various manners such as immune response, coagulation and adhesion. Finding out significance of blood type compatibility in transfusion medicine and maternal-fetal blood group incompatibility in various pregnancy outcomes, is the other objective of this review. Hence, it can be realized that the correlation between the genetic and medical importance of blood group differences can be applied to help in risk assessment of diseases and the creation of personalized medicine.