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Abstract
Objective:
To determine the early clinical outcome, postoperative morbidity and mortality of pancreaticoduodenectomy (Whipple procedure) in a newly established hepatobiliary unit.
Study Design: Retrospective cohort study.
Place and Duration of Study:
The study was done in the Department of General Surgery, Unit-I, Ward-3, Jinnah Postgraduate medical Centre(JPMC), Karachi, between January 2023 and February 2026.
Methodology:
Retrospectively, medical records of patients who underwent pancreaticoduodenectomy were reviewed within the study period. The demographics, clinical presentation, operative, ICU stay, postoperative complications and mortality were data collected. All procedure was done with open method by the classical Whipple technique.
Results:
A total of 29 patients were included, with 24 (82.8%) males and 5 (17.2%) females. The mean age was 55 ± 10 years. Obstructive jaundice was the most common presenting symptom, and periampullary carcinoma was the most frequent indication (55.2%). All patients required ICU admission postoperatively, with a mean ICU stay of 2–3 days. Postoperative complications occurred in 7 patients (24.1%), including hepaticojejunostomy leak in 2 (6.9%), gastrojejunostomy leak in 1 (3.4%), and surgical site infection in 4 (13.8%). The overall postoperative mortality rate was 13.8% (n = 4).
Conclusion:
Pancreaticoduodenectomy is safely performed in new hepatobiliary units with an acceptable morbidity and mortality, when there is proper surgical expertise and postoperative care are available.