ROLE OF INTRAVENOUS AMINO ACID INFUSION (PAN-AMIN G) IN IMPROVING LIQUOR QUANTITY IN IDIOPATHIC OLIGOHYDRAMNIOS

Abstract

Background: Idiopathic oligohydramnios is associated with increased risks of intrauterine growth restriction, cord compression, and perinatal morbidity. Objective: To compare the effectiveness of intravenous amino acid infusion (PAN-AMIN G) versus normal saline in improving AFI in women with idiopathic oligohydramnios. Methods: This randomized controlled trial was conducted at the Department of Obstetrics and Gynecology, Services Hospital, Lahore from December 2024 to May 2025. A total of 60 women with idiopathic oligohydramnios (AFI <5 cm) after 28 weeks of gestation were included through consecutive sampling and randomized into two groups: Group A received intravenous normal saline (500 ml drip), while Group B received intravenous PAN-AMIN G (200 ml infusion), administered on alternate days for six doses. Results: The mean AFI increased significantly in both groups; however, the rise was greater in the PAN-AMIN G group (baseline 3.9 ± 0.7 cm to 7.0 ± 0.8 cm; mean change 3.1 ± 0.7 cm) compared to the saline group (baseline 3.8 ± 0.6 cm to 4.9 ± 0.7 cm; mean change 1.1 ± 0.3 cm) (p<0.001). Normalization of AFI (>7 cm) was achieved in 63.3% of the amino acid group versus none in the saline group (p<0.001). PAN-AMIN G was well tolerated, with only mild transient side effects. Conclusion: Intravenous amino acid infusion (PAN-AMIN G) is significantly more effective than normal saline in improving liquor quantity in idiopathic oligohydramnios, offering a safe and practical therapeutic option. Larger trials assessing perinatal outcomes are recommended.