FABRICATION, AND CHARACTERIZATION OF LEDIPASVIR CARRIER METALLIC NANOPARTICLES

Abstract

The drug-delivery system based on nanostructured permits the development of new area for the transport and measured release of the drug molecules in the complicated diseased environment with limited side effects to the normal tissues of the living systems. The present study focused on the fabrication of the nano-carrier drug delivery system based on biocompatible molecules to increase the stability and strength of the ledipasvir. The Zinc and copper metals were selected due to their intrinsic biological application for synthesizing drug loaded metallic nanoparticles. The characteristics peaks for ZnNPs and CuNPs was achieved on 325nm and 260nm respectively by ultra-violet visible spectroscopy and in the finger print region of infra-red spectra which confirms the synthesis of nanoparticles. The % drug encapsulation value was found to be 16.17 for CuNPs and 35.72% for ZnNPs. The shape and size of synthesized nanoparticle was resolute by SEM and AFM. Simultaneous TGA-DSC analysis was conducted to study the kinetic and thermal parameters of encapsulated nanoparticles. The drug encapsulated CuNPs starts to degrade at 410 ^oC which depicted the more thermal sustainability whereas ZnNPs is thermally labile but have more purity as sharp endothermic peak was observed in the DSC curve. The kinetic parameters were calculated by Horowitz-Metzger equation.