SYNTHESIS AND CHARACTERIZATION OF Cu DOPED MANGANESE OXIDE NANOPARTICLES: EVALUATION OF ANTIBACTERIAL, ANTIFUNGAL, AND ANTIOXIDANT PROPERTIES

Abstract

Introduction: Nanotechnology is being used in disease diagnosis, sensors, imaging, agriculture, chemistry, medication, catalysis, pollution degradation etc.  Ag, Cu, and other metal nanoparticles have antimicrobial properties. Aim: Current research was performed to assess the antibacterial, antifungal and antioxidant potential of Cu doped manganese oxide. Material and Method: Hydrothermal synthesis was used to create the necessary nanoparticles for this investigation. The characterization of the produced material was done using powder X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), and Energy Dispersive X-ray (EDX) to validate its nanoparticle property.   Nanoparticles' antibacterial ability was tested on Klebsiella pneumonia, E. coli, and Bacillus subtilis. Klebsiella pneumonia was treated with Levofloxacin, Norfloxacine, Gentamicin, Chloramphenicol, Trimethoprim, Amoxicillin, and Ciprofloxacin antibiotics. Results: Levofloxacin, Norfloxacine, Gentamicin, Chloramphenicol, Amoxicillin, and Ciprofloxacin all had antibacterial action according to the data, however Trimethoprim did not.  The nanoparticles showed no antibacterial activity against Klebsiella pneumonia but were effective against E. coli and Bacillus subtilis. In the antifungal activity test, the nanoparticles inhibited the growth of Fusarium equiseti, with the zone of inhibition increasing over time, but had no effect on Rhizopus stolonifer. Additionally, the nanoparticles exhibited antioxidant activity, with a maximum of 67% at a concentration of 0.1 mg/2 ml, although this was less than the antioxidant activity of ascorbic acid, which showed 90% activity at the same concentration. Conclusion: The Cu doped manganese oxide nanoparticles demonstrated promising biological activities, including antibacterial effects against E. coli and Bacillus subtilis, antifungal activity against Fusarium equiseti, and antioxidant properties. These findings suggest potential applications for these nanoparticles in biomedical and pharmaceutical fields, such as the development of new antimicrobial and antioxidant agents. However, further research is needed to fully explore their efficacy, safety, and potential uses.