Abstract
SYNOPSIS:
Diprivan is frequently used medicine for induction of anesthesia. It often causes discomfort when it is injected. To compare how well depo-medrol and lignocaine work in reducing this pain, we carried out a double-blind study on patients who were having cardiac surgery.
METHOD:
The study involved 180 adult patients who were scheduled for elective cardiac surgery.
Participants were randomly assigned to three groups: one received normal saline (Group S, n = 60), another received lignocaine 20 mg (Group L, n = 60), and the third received depo-Medrol 125 mg diluted in 2 ml of distilled water (Group MP, n = 60). The assigned medication was given after applying a tourniquet, and the tourniquet was released after one minute. Then, one fourth of the total diprivan dose (2 mg/kg) was given at a rate of 0.5 ml per second. Pain from the diprivan injection was measured using a four-point verbal rating scale. Data was analyzed using Student’s t-test, along with Chi-square or Fisher’s exact test as appropriate.
RESULT:
Pain occurred in 70.9% of patients in the saline group, compared to 30.9% in the lignocaine group and 36.4% in the depo-medrol group.
Both Depo-medrol and lignocaine were linked to significantly lower pain than saline (P value < 0.012).
CONCLUSION:
Administering intravenous depo-medrol before treatment was found to be as effective as lignocaine in reducing the pain from diprivan injection