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Abstract
Objective: ARDS is a potentially lethal disorder, which causes serious morbidity. The study objective was to identify the prognostic value of the lactate dehydrogenase to albumin ratio (LAR) on in-hospital mortality rates in ARDS patients.
Material and methods: The study was a cross-sectional study carried out at the Jinnah Postgraduate Medical Centre, Karachi, with the institutional review board approval, during a period of six months between February 2025 and July 2025. The consecutive non-probability sampling was used to select patients who were aged over 15 years and had ARDS. The sample size of the patients was 75 who were enrolled and monitored up to the time of admission in the hospital or death. The SPSS version 25 was used to analyze the data and the association was tested with the chi-square test where p ≤ 0.05 was taken to be statistically significant.
Results: Out of 75 patients, 60% were above 40 years of age. Most patients presented with severe respiratory distress, with 74.7% having grade 3–4 dyspnea and 85.3% exhibiting tachypnea. Laboratory evaluation showed mean lactate dehydrogenase-to-albumin ratio (LAR) of 26.7 ± 17.8. The overall in-hospital mortality was 69.3%. Mortality was significantly higher in patients with elevated LAR, with all patients in Group 3 (LAR >30.9) experiencing death (p < 0.001).
Conclusion: To sum up, the lactate dehydrogenase to albumin ratio is an effective predictor of mortality in-hospital in a patient with ARDS, and greater LAR values positively correlate with worse clinical results.