Abstract
Nanosponges are a new kind of porous nanoscale delivery mechanism that offers several advantages over traditional methods of administering medication, including the potential to enhance drug solubility, improve drug stability, and provide controlled-release properties. The objective of this research effort was to produce and assess nanosponges that provide sustained release of anti-inflammatory medications. Antiinflammatory medications were incorporated into nanosponges made with appropriate combinations of polymer and crosslinking agent through established preparation techniques followed by incorporation of the compound. Nanosponges were evaluated with respect to particle size, surface morphology, drug-loading efficiency, production yield, and in vitro drug release characteristics. Characterisation data indicated that the antinflammatorynanosponges were prepared as spherical, porous structures that contained an adequate drug-load. The in vitro release data showed that these nanosponges produced a prolonged and sustained-release profile relative to the standard form of the antinflammatory medications, thereby maintaining therapeutic drug concentrations over a longer time frame. The sustained-release profile exhibited by the nanosponges will contribute to reducing the frequency with which dosages must be administered, improving patient compliance, and helping to decrease the incidence of side effects associated with frequent administration of conventional forms of antiinflammatories. Results obtained from stability testing also demonstrated that the disposition and functionality of the antinflammatorynanosponged products were not affected by time or specified storage conditions