Abstract
Objective: To Evaluate Effectiveness of Lignocaine and Ondansetron in Attenuating Propofol Injection Pain
Material & Method: This quasi-experimental study was carried out in the Pharmacy & Anesthesia Department; University of Lahore affiliated Hospital over a period of 4 months, from November 2025 to February 2026. To measure pain effects at laparoscopic cholecystectomy among adult patients.The patients were received 0.5mg/kg Lignocaine through the vein or 8mg Ondansetron before they received propofol treatment. Medical staff evaluated patients' pain levels on a standard scale while recording their vital signs.Data were analysed by SPSS 21.0. The categorical data was analysed through chi-square and evaluated continuous values with an independent t-test at a significance level of 0.05.
Results: At a statistical significance of p<0.001, lignocaine provided superior pain relief from propofol compared to ondansetron.15% of patients in the Lignocaine group reported having severe pain, compared to 32% of patients in the Ondansetron group. Short-lived decreases in heart rate and blood pressure were produced by ondansetron, although modest skin problems were created by lignocaine.
Conclusion: Both lignocaine and ondansetron with propofol significantly reduce pain; nevertheless, lignocaine is a more effective therapy than ondansetron. Compared to ondansetron, which resulted in slight, transient alterations in blood pressure, lignocaine caused less severe skin pain. Ondansetron should be used as necessary, and research supports the continued use of Lignocainet to the extent that it is comfortable. Better medication combinations must be tested in order to enhance how patients respond to the induction of anesthesia.