Abstract
Introduction: Hypertension is a serious public health problem in the entire world and one of the leading causes of morbidity and mortality associated with cardiovascular and renal disorders. Recent studies suggest that SUA might play a critical role in the development and progression of hypertension. Therefore, this particular study has been undertaken to identify serum uric acid as a predictor for hypertensive subjects.
Materials and Methods: This was a cross-sectional study done at the Department of Pathology/Clinical Laboratory, City Care Lab, Sargodha. There were 343 subjects comprising normotensive and hypertensive subjects. Demographic and clinical data were recorded by means of a structured questionnaire. Levels of serum uric acid were determined by the Enzymatic Colorimetry method which is also referred to as the Uricase-Peroxidase method. After the venous blood samples were collected under aseptic technique, the collected data were analyzed using SPSS software. The appropriate tests were applied, and a value of p ≤ 0.05 was considered statistically significant.
Result: It was found that the mean serum uric acid value in patients with hypertension was significantly higher (7. 42 ± 2. 44 mg/dL) when compared to that in patients with normal blood pressure (5. 73 ± 2. 79 mg/dL). In addition, there was also a considerable positive relationship between serum uric acid and systolic blood pressure (r = 0. 283, p 0. 001) as well as diastolic blood pressure (r = 0. 277, p 0. 001). This finding suggests that elevated serum uric acid levels may be associated with hypertension.
Conclusion: As a whole, the results of this study demonstrate a significant correlation between serum uric acid levels and hypertension. The latter factor could be a good, simple, and cost-effective marker for the diagnosis and management of hypertensive individuals. To examine the clinical significance and associations between serum uric acid and hypertension, further studies are recommended.