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Abstract
OBJECTIVE:
To compare the prevalence, severity, management of anemia between patients undergoing haemodialysis (HD) and peritoneal dialysis (PD) in a tertiary care setting.
STUDY DESIGN:
Prospective cohort study.
PLACE AND DURATION OF STUDY:
The study took place at the Nephrology Department, The Indus Hospital, Karachi, Pakistan For six months.
METHODOLOGY:
A total of 102 adult patients with end stage renal disease were enrolled and equally divided into HD (n=51) and PD (n=51) groups. Haemoglobin levels, anaemia severity, erythropoiesis-stimulating agent (ESA) use, iron supplementation, and transfusion requirements were assessed according to KDIGO guidelines. Statistical analysis was performed using SPSS Vol 25, applying independent t-test and chi-square test to test significance at the level of <0.05.
RESULTS:
Mean haemoglobin levels were significantly higher in PD patients compared to HD patients (10.6 ± 1.4 vs. 9.8 ± 1.5 g/dL; p=0.001). Anaemia prevalence was higher in the HD group (52.5% vs. 32.5%; p=0.011), with severe anaemia more frequent in HD patients (16.7% vs. 3.8%; p=0.043). Although ESA use was comparable, HD patients required significantly higher doses (195.2 ± 72.3 vs. 153.1 ± 58.4 IU/kg/week; p=0.001). Iron supplementation and blood transfusion rates were also significantly higher in the HD group.
CONCLUSION:
Peritoneal dialysis is associated with better anaemia control and lower treatment burden compared to haemodialysis. Dialysis modality should be considered an important factor in anaemia management strategies in resource-limited settings.