Abstract
Veno thromboembolism (VTE; DVT, PE) is one of the frequent and one of the riskier complications in surgical patients. The choice and use of effective thromboprophylaxis is essential. The primary aim of this meta-analysis and systemic review was to compare efficacy and safety of various thromboprophylaxis regimens (direct oral anticoagulants -DOACs-, low-molecular-weight heparin -LMWH-, aspirin and mechanical techniques) to prevent post-surgical VTE. Fifteen studies were selected for inclusion. We concluded based on the meta-analysis that: the DOACs are equally as effective as the LMWHs in most cases of cancer surgeries in preventing VTE but have a non-statistical increased overall risk of major bleedings. Aspirin seem to work in some orthopedic surgeries; they have an almost non statistically lower trend to bleeding. and mechanical combined with pharmacological method outperform each approach by own.