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Abstract
The aim was to perform a significant cumulative comparative analysis of the sex-based (male and female) and medication-based (monotherapy and combination therapy) statistics of social/behavioural socioeconomic and clinical factors (age, lifestyle, income, ABI, 10g MFT, HbA1c, Wagner grade) and assess the cumulative risk factor load of age, lifestyle, source of income and clinical factors (ABI, 10g MFT, HbA1c, Wagner grade) in this sample.
Methods: The data set of the same 100 consecutive cross-sectional sample from the GIMS OPD (June 2021 - January 2022) were analysed. The following graphs and cross-tabulations were analysed from the parent thesis: The graph of Wagner grade vs Medicine and Diet (Figure 4.17); Age vs Lifestyle and Income (Figure 4.18); Anatomical examination vs Medicine type (Figure 4.19); HbA1c vs Medicine cross-tabulation (Table 4.4); and the comparative graph- Wagner grade vs ABI and 10g MFT (Figure 4.21). SPSS v20.2.0 was used for data analysis.
Results: The cumulative analysis from these confirmed that: (1) Of all the monotherapy patients, 95.7% were HbA1c >8% (untreated diabetes) versus 32.1% of combination therapy patients; (2) The 3 patients on combination+supplementary therapy were the only ones with HbA1c of 6.7-7% - the only group that had diabetes under control; (3) DFU cases were most common among 45-65 years without specified lifestyle or source-of-income; (4) With lower ABI (0-0.4) patients had lower 10g MFT (0-2 positive sites), confirming the co-evolution of PVD-PDN; (5) Monotherapy patients rated more in the Grade 3-5 ulcer grades while the lower peak of combination patients (1-2) confirmed the medication's effect on ulcer severity.
Conclusion: The cumulative analysis reveals that DFU severity in Khairpur reflects the influence of the combined action of multiple risk factors - socioeconomic disparities, lifestyle risk factors, untimely pharmacotherapy and progressive PDN/PVD. DFUs must be prevented by multifactorial action.