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Abstract
Background: Laparoscopic cholecystectomy has been considered as the gold standard in terms of the treatment of the symptomatic, cholelithiasis secondary to its mild invasiveness, reduced postoperative piety, reduced hospitalization and short duration of recovery relative to open surgery. Nevertheless, as much as these benefits exist, the process comes with large intraoperative hemodynamic changes.
Purpose: The objective of the proposed study is to find out the impact of dexmedetomidine which is a highly selective alpha-2 adrenergic agonist on the maintenance of intraoperative blood flow in laparoscopic cholecystectomy patients under general anesthesia.
Methods: Four randomized clinical trials (eighty patients of ASA physical status I and II) were carried out. A randomized assignment of participants in Dexmedetomidine group v/s Control group was done. The intervention group was loaded at 1 µg/kg in an intravenous injection then was continuously infused 0.5 µg/kg/h in the procedure.
Findings: The outcomes showed that, in terms of alterations in the heart rate and blood pressure during intraoperative period, dexmedetomidine decreased significantly as compared to the control group. Furthermore, patients undergoing dexmedetomidine treatment had a reduced number of rescue analgesics as well as an enhanced level of sedation with no significant adverse event.
Conclusion: Dexmedetomidine is an effective agent for maintaining intraoperative hemodynamic stability and enhancing postoperative recovery in laparoscopic cholecystectomy patients.