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Abstract
Objective:
During early pregnancy, determining the relationship between biochemical hyperthyroidism and hyperemesis gravidarum.
Study Design:
It's a case-control study.
Place and Duration of study:
Department of Gynecology and Obstetrics at Khyber Teaching Hospital, Peshawar, from March 2025 to July 2025, wherein the aim was to define the relationship between hyperthyroidism and HG in early pregnancy.
Methodology:
84 primigravidae in the first trimester were recruited, consisting of 42 with HG and 42 gestational-age-matched controls. The level of serum thyroid-stimulating hormone (TSH) was tested, and hyperthyroidism was operationally defined as TSH <0.3mIU/L.
Results:
The statistical analyses were done in SPSS version 25.0 and Chi-square or Fisher exact testing, odds ratios calculation, and logistic regression modelling. The prevalence of hyperthyroidism was found to be 23.8% in HG compared to 2.4% in controls (p=0.004), and the presence of HG was found to significantly increase the risk of hyperthyroidism (OR=0.078; 95% CI=0.009-0.642). HG was proven to be an independent predictor of suppressed TSH levels by multivariate regression.
Conclusion:
These findings support a strong linkage of HG and biochemical hyperthyroidism during early pregnancy and support the hypothesis of thyroid-stimulation mediated by hCG, and promote regular TSH screening of individuals with HG.