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Abstract
Objective: To compare the mean duration of prolongation of pregnancy in patients presenting with preterm labor treated with oral nifedipine versus vaginal progesterone.
Study Design: Randomized controlled trial.
Place and Duration: Teaching Department of Gynecology and Obstetrics, Aziz Bhatti Shaheed Hospital, Gujrat, from March 2025 to July 2025.
Methodology: A total of 60 pregnant women with singleton pregnancies presenting with preterm labor were enrolled and randomly allocated into two equal groups. Group A (n = 30) received oral nifedipine, while Group B (n = 30) received vaginal progesterone. The primary outcome measure was the mean duration of pregnancy prolongation. Demographic variables and obstetric characteristics were recorded.
Results: The mean duration of pregnancy prolongation was significantly longer in the vaginal progesterone group compared to the oral nifedipine group (32.4 ± 8.5 days vs 20.1 ± 6.8 days, p <0.001). Baseline characteristics including age, body mass index, parity, and history of preterm labor were comparable between the two groups.
Conclusion: Vaginal progesterone is more effective than oral nifedipine in prolonging pregnancy in women presenting with preterm labor, with a favorable safety profile. Its use may be preferred for sustained pregnancy prolongation in appropriate clinical settings.