Keywords
How to Cite
Abstract
Background: Diabetic Mellitus Type-II is multi metabolic disorder. Hyperglycemia condition slowly damage Cardiovascular disease (CVD) system. Research has proved that through biomarkers CVD disorder could be diagnosed at early stage of complications. The aims of this study was to determine the frequency of cardiovascular disorders in Diabetic Mellitus Type-II patients and to find out the abnormalities in cardiac biomarkers and lipid profile parameters and also evaluate the role of cardiac markers for the assessment of pre cardiovascular complication in Diabetic Mellitus Type-II patients.
Material & Methods: This research was carried out at Institute of Biochemistry University of Sindh Jamshoro. Total 200 cases were selected, 100 Diabetic subjects and 100 non diabetic healthy controls including (males and females) age between 30 to 60 years were selected in the study. All samples were collected from OPD clinics of Liaquat University of Medical Health Sciences (LUMHS) Hyderabad/Jamshoro and ISRA University Hospital Hyderabad. All biochemical parameters of Diabetic subjects and controls were analyzed on C311, Hitachi 902 Roche company automatic analyzer by spectrophotometer method.
Results: Total 200 subjects were selected in the study, 100 Diabetes Mellitus Type II patients and 100 non diabetic healthy controls were selected. Male were found 63% and female were found 37%, while in non diabetic healthy controls group males were found 66% and females were found 34%. The Mean±SD age of diabetic patients was 47.2±7.3years and control group Mean±SD of age42.3±8.3 years. Mean±SD was calculated for Age, BMI, BP, all biochemical markers and analyzed respectively.
Conclusion: All Diabetic subjects were divided into three groups. Present study showed that, the level of HbA1c, BMI, BP, Cholesterol, Triglyceride and LDL have been observed higher in 2ndGroup, and HDL found lower.