Abstract
The paper investigates indomethacin's chemical reactions and yields. Numerous compounds' cytotoxic and anti-cancer qualities were examined. A comparison of the Hemotoxicity profiles of the generated compounds was made. Indomethacin works well to reduce pain and inflammation. There are anti-inflammatory and anti-cancer effects of indomethacin. The study assesses the cytotoxicity of synthetic derivatives. In order to improve thrombolytic efficacy, indomethacin reduces inflammation. New anti-cancer drugs are created using well-known inhibitors. A variety of derivatives have been produced using various techniques, employed for various purposes, and their thrombolytic and hemolytic activity has been examined. The synthesized derivatives of indomethacin 3a-g yields 42- 60%.