SYNTHESIS AND BIOLOGICAL SCREENING OF NOVEL ORGANOTIN (IV) COMPLEXES OF CARBOXYLATE BASED LIGANDS

Abstract

The purpose of this research was synthesis and characterization of different di and triorganotin (IV) complexes by combining organotin (IV) compounds of type R₃SnL and R₂SnL₂ (R=methyl, n-butyl, phenyl) with two newly prepared ligands -2-((3,4-dichlorophenylcarbamoyl)benzoic acid and (E)-4-methyl-5-(4-methylthiazole-3(2H)-yl)5-oxopent-3-enoic acid in 1:1 and 1:2 depending on tin metal oxidation state. From FT-IR data, ligands and organotin (IV) complexes structures were ascertained. All organotin (IV) complexes exhibited absence of hydroxyl group broad band (deprotonation of carboxylate group), existence of sharp, medium intensity bands in lower wave number region indicating presence of Sn-C, Sn-O bond and revealed C-O-Sn bridge which confirmed complexation phenomena. Antibacterial activities were performed against two bacterial strains. Ligand-2 was more active than ligand-1 and organotin (IV) complexes with ligand-2 were more promising and biologically active than ligand-1 and its complexes