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Abstract
Background: Hypothyroidism is a common endocrine disease which is often linked with dyslipidemia that is a major cause of cardiovascular disease. Thyroid-Stimulating Hormone (TSH) is the key in lipid metabolism, yet the concrete relationship between the levels of TSH and the lipid profile abnormality in the hypothyroid population of Lahore, Pakistan, has not been sufficiently investigated.
Objective: The aim of the study was to determine the relationship between Thyroid-Stimulating Hormone (TSH) and dyslipidemia in patients with diagnosed hypothyroidism in Lahore.
Methods: This research was a cross-sectional study done on 100 hypothyroid patients. To assess variables of serum TSH and lipid profile, the blood samples were taken to measure Lipid profile. Version 21 of SPSS was used to analyze the data. The rank correlation of Spearman was employed to determine the association between TSH and lipid markers as the non-normal data distribution was established.
Result: The mean age of the study population was 44.84 +- 17.39 years with a small prevalence of males (57%). Most participants (63% of them) had high levels of TSH. Dyslipidemia was very high, 44 percent of this population is at the high-risk group of Total Cholesterol and 41 percent of LDL and Triglycerides. The statistical significance of positive correlations of TSH and TC, LDL, VLDL, and Triglycerides was found by Spearman correlation analysis (r = 0.577 p<0.001, r = 0.534 p <0.001, r = 0.485 p <0.001 and r = 0.496 p <0.001, respectively). There was a significant negative correlation between TSH and HDL ( r = -0.354, p<0.001). Conclusion: The research shows that there is a significant and high correlation that exists between high TSH and an atherogenic lipid profile in patients with hypothyroidism. These results provide support to the urgent necessity of regular lipid testing and combined treatment of dyslipidemia in patients with hypothyroidism to reduce the risks linked to cardiovascular diseases.