Keywords
How to Cite
Abstract
Objectives:Diabetes is a metabolic disorder that affects various body organs and hormones, especially sex hormones. Different studies have found the association of sex hormones with diabetes differently. This study aims to accurately compare serum total testosterone, FSH, and LH levels in diabetic and non-diabetic individuals, as well as the relationship between testosterone and with age of patients and the duration of diabetes.
Methods:
This case-control study was conducted from June to October 2023 at Lady Reading Hospital, Peshawar, Pakistan, involving 101 diabetic males and 101 non-diabetic individuals. Blood was collected in a gel tube, centrifuged, and HbA1c, Serum total testosterone, FSH, and LH were tested by cobass411 through the Electrochemiluminescence immunoassay (ECLIA) method.
Results:
Serum total testosterone was significantly lower in type 2 diabetic patients (2.41±1.76) than in non-diabetic individuals (4.49±1.34) (p value=0.000). LH was significantly higher in diabetic (7.93±6.25) than non-diabetic individuals (5.13±2.02) (p value=0.000), with no effect on FSH in both groups. The duration of diabetes and testosterone had no significant relationship. In contrast, a significantly negative relationship was seen in both age groups: Group 1 =35-45 (mean rank=108.04) and Group 2 = 46-75 (mean rank=90.99), and testosterone level (p value=0.041).
Conclusion:
In diabetic patients, diabetes affects testosterone and LH as compared to non-diabetic individuals, whereas FSH remains normal in both groups. Testosterone decreases as age increases in diabetic patients, but the duration of diabetes has no impact on testosterone levels.