Keywords
How to Cite
Abstract
In the drug development process, active pharmaceutical ingredients (APIs) plays a crucial role. To ensure safety and efficacy, they undergo rigorous testing, and APIs can be approved for use in medications, paving the way for new treatments. Acute oral and dermal toxicity evaluations of a composite hydrogel synthesized from Mimosa pudica seed mucilage and methacrylic acid were conducted according to OECD 402 and 420 guidelines. In addition, using the Draize scoring system, an ocular toxicity study was conducted. The laboratory animals (rabbits) were categorized into four distinct groups. The animals of category A were served as controls and no dose was given to them and a single dose of composite hydrogel was administered to animals of categories B, C, and D. Throughout the 14 days of toxicity study period, all the animals were remained alive and any kind of significant adverse effects in animals was not observed. After 14 days, the blood analysis and biochemical test were performed. For organ weight measurement, the vital organs from the rabbits were taken. The findings collectively shows that the synthesized composite hydrogel is a safe material and can be used in drug delivery systems as a promising non-toxic excipient.