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Abstract
Objective: To determine the mean change in intraocular pressure after Bevacizumab injection in patients of diabetic macular oedema (DME).
Methods: This quasi-experimental study involving 100 patients of DME was conducted in the department of ophthalmology, King Edward Medical University/Mayo Hospital, Lahore from November 2024 to April 2025. The intravitreal injections were carried out in a sterile environment within the operating theater using topical anesthesia. A dose of Avastin (1.25 mg, or 0.05 ml) was injected into the vitreous at specific distances from the limbus. Post-injection, patients were positioned seated, and IOP measurements were taken immediately after the injection, as well as at intervals of 5 minutes and 30 minutes thereafter.
Results: The average age of the participants was 53.1±5.9 years. The gender distribution was noted, showing that 47% participants were male, while 53% participants were female. The duration of diabetic macular oedema (DME) was 8.5±3.2 months. The mean IOP prior to injection was 12.8±2.3 mmHg. After the injection, the mean IOP increased significantly to 22.4±3.7 mmHg, the statistical analysis yielded a p-value of less than 0.0001.
Conclusion: There is a significant increase in IOP after intravitreal bevacizumab injection for the treatment of diabetic macular oedema.