Abstract
This study aimed to investigate the associations between lipid profiles, gestational age, mode of delivery, and gravidity in normotensive and pre-eclamptic pregnant women. A total of 111 participants (92 normotensive and 19 pre-eclamptic) were enrolled TTH Timergara teaching hospital Dir Lower between March 2024 and August 2024. Data was collected on age, gravida, gestational age at delivery, mode of delivery, and lipid profiles, including total cholesterol (TC), HDL, LDL, VLDL, and triglycerides (TG).
Results revealed that pre-eclampsia was associated with significant lipid profile abnormalities. Pre-eclamptic women exhibited higher levels of total cholesterol (222.36 ± 43.68 mg/dL), LDL (131.87 ± 24.74 mg/dL), VLDL (37.71 ± 8.10 mg/dL), and triglycerides (183.48 ± 35.53 mg/dL), while HDL levels were significantly lower (38.69 ± 7.50 mg/dL) compared to normotensive women. Additionally, pre-eclampsia was strongly associated with preterm deliveries (62.11% in pre-eclampsia vs. 5.45% in normotensive) and caesarean section (LSCS) deliveries (45.44% in pre-eclampsia vs. 12.98% in normotensive). Gravidity also played a key role, with primigravida (first-time pregnancies) being more common in the pre-eclampsia group (24.08%) compared to normotensive women (76.92%).
These findings suggest that lipid profile abnormalities are closely linked to pre-eclampsia and may serve as potential biomarkers for early detection and monitoring of the condition. The study highlights the importance of early prediction tools for pre-eclampsia and advocates for further research to identify specific markers that can help predict maternal and perinatal outcomes in high-risk pregnancies.
