THE RELATIONSHIP OF PRE-DONATION CBC PARAMETERS ON PLATELET YIELD BY SINGLE DONOR PLATELETPHERESIS

Abstract

Objectives: To determine the correlation of different Complete Blood Count (CBC) parameters with platelet yield by single donor (SD) plateletpheresis

Methods: A cross-sectional study was conducted at the Blood Bank of Pathology Department, Mayo Hospital, Lahore, from 3rd August 2024 to 2nd November 2024 (3-month duration), comprising 154 patients. After obtaining informed consent with IRB approval(768/RC/KEMU), Blood counts for each donor were determined using a calibrated automated analyzer (Beckman Coulter). Plateletpheresis was subsequently conducted using a continuous flow cell separator apheresis machine with closed-system kits in accordance with standard operating procedures. The platelet yield was documented following procedure completion. Statistical analysis was performed using SPSS v.26.0, where Pearson correlation coefficients were calculated and results with p ≤ 0.05 were considered statistically significant.

Results: Platelet yield was seen strongly correlated to age, weight, hemoglobin levels and most importantly pre-donation platelet counts of donors. Blood group, Rh factor, total leukocyte count and procedure time however did not affect platelet yield significantly.

Conclusions: Donor’s pre-donation platelet counts, age and weight of donor and other CBC parameters like hemoglobin had positive correlation with platelet yield. These factors can contribute to selection of donors to enhance platelet yield